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Volume 32, Number 1—January 2026

Research

Enhanced Isolation and Detection of COVID-19 in Hospitalized Patients Undergoing Antiviral Therapy

Ranawaka A.P.M. PereraComments to Author , Andrew Marques, Jevon Graham-Wooten, Li Hui Tan, Noam Cohen, Kyle Rodino, Ronald G. Collman, Frederic D. Bushman, and Susan R. Weiss
Author affiliation: Department of Veterans Affairs, Philadelphia, Pennsylvania, USA (R.A.P.M. Perera); University of Pennsylvania, Philadelphia (R.A.P.M. Perera, A. Marques, J. Graham-Wooten, L.H. Tan, N. Cohen, K. Rodino, R.G. Collman, F.D. Bushman, S.R. Weiss)

Main Article

Figure 6

Efficiency and possible routes of infectious viral particle internalization for mCherry-labeled wild-type SARS-CoV-2 virus in Vero E6, Vero E6 T2, and Vero E6 A2T2 cell lines from study on the enhanced isolation and detection of COVID-19 in hospitalized patients undergoing antiviral therapy. A) Inoculated cells, singular cells or fused (in red). B) Cytopathic effects induced by SARS-CoV-2 XBB.1 viral inoculation, focal areas of rounded cells or regions of fused cells forming syncytia or giant cell structures across the different cell lines. Vero E6 T2, Vero E6 cells expressing transmembrane protease serine 2; Vero E6 A2T2, Vero E6 cells expressing both transmembrane protease serine 2 and angiotensin-converting enzyme 2.

Figure 6. Efficiency and possible routes of infectious viral particle internalization for mCherry-labeled wild-type SARS-CoV-2 virus in Vero E6, Vero E6 T2, and Vero E6 A2T2 cell lines from study on the enhanced isolation and detection of COVID-19 in hospitalized patients undergoing antiviral therapy. A) Inoculated cells, singular cells or fused (in red). B) Cytopathic effects induced by SARS-CoV-2 XBB.1 viral inoculation, focal areas of rounded cells or regions of fused cells forming syncytia or giant cell structures across the different cell lines. Vero E6 T2, Vero E6 cells expressing transmembrane protease serine 2; Vero E6 A2T2, Vero E6 cells expressing both transmembrane protease serine 2 and angiotensin-converting enzyme 2.

Main Article

Page created: December 30, 2025
Page updated: January 29, 2026
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