Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Volume 32, Number 1—January 2026

Research

Enhanced Isolation and Detection of COVID-19 in Hospitalized Patients Undergoing Antiviral Therapy

Ranawaka A.P.M. PereraComments to Author , Andrew Marques, Jevon Graham-Wooten, Li Hui Tan, Noam Cohen, Kyle Rodino, Ronald G. Collman, Frederic D. Bushman, and Susan R. Weiss
Author affiliation: Department of Veterans Affairs, Philadelphia, Pennsylvania, USA (R.A.P.M. Perera); University of Pennsylvania, Philadelphia (R.A.P.M. Perera, A. Marques, J. Graham-Wooten, L.H. Tan, N. Cohen, K. Rodino, R.G. Collman, F.D. Bushman, S.R. Weiss)

Main Article

Figure 4

Minor variants identified after passage 1 from SARS-CoV-2 BA.5 Omicron variant positive nasal swab specimens in 3 cell lines Vero E6, Vero E6 T2, and Vero E6 A2T2 from study on the enhanced isolation and detection of COVID-19 in hospitalized patients undergoing antiviral therapy. This figure shows the minor variants observed in the 3 virus culture isolates obtained after passage 1 from nasal swab samples from patients 1, 17, and 20 that were SARS-CoV-2 positive and were a BA.5 Omicron variant. Vero E6 T2, Vero E6 cells expressing transmembrane protease serine 2; Vero E6 A2T2, Vero E6 cells expressing both transmembrane protease serine 2 and angiotensin-converting enzyme 2.

Figure 4. Minor variants identified after passage 1 from SARS-CoV-2 BA.5 Omicron variant positive nasal swab specimens in 3 cell lines Vero E6, Vero E6 T2, and Vero E6 A2T2 from study on the enhanced isolation and detection of COVID-19 in hospitalized patients undergoing antiviral therapy. This figure shows the minor variants observed in the 3 virus culture isolates obtained after passage 1 from nasal swab samples from patients 1, 17, and 20 that were SARS-CoV-2 positive and were a BA.5 Omicron variant. Vero E6 T2, Vero E6 cells expressing transmembrane protease serine 2; Vero E6 A2T2, Vero E6 cells expressing both transmembrane protease serine 2 and angiotensin-converting enzyme 2.

Main Article

Page created: December 30, 2025
Page updated: January 29, 2026
Page reviewed: January 29, 2026
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external