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Volume 24, Number 10—October 2018

Research

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira WatanabeComments to Author , and Katsuhiko Kamei
Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Figure 1

Growth inhibition by lovastatin and polyene drugs in azole-susceptible and azole-resistant Aspergillus fumigatus isolates from a patient in Japan. Growth inhibition tests were conducted by disk assay. IFM 60814 is a susceptible isolate identified on the first date of testing; IFM 63240 is a resistant isolate identified on the third date of testing, with mutations in hmg1. The results of repeated experiments are expressed as mean ± SD (error bars).

Figure 1. Growth inhibition by lovastatin and polyene drugs in azole-susceptible and azole-resistant Aspergillus fumigatus isolates from a patient in Japan. Growth inhibition tests were conducted by disk assay. IFM 60814 is a susceptible isolate identified on the first date of testing; IFM 63240 is a resistant isolate identified on the third date of testing, with mutations in hmg1. The results of repeated experiments are expressed as mean ± SD (error bars).

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
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