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Volume 24, Number 10—October 2018

Research

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira WatanabeComments to Author , and Katsuhiko Kamei
Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Figure 2

Total ergosterol content of azole-susceptible and azole-resistant Aspergillus fumigatus isolates in Japan. Ergosterol was quantified in the sets of IFM 60814, a susceptible isolate identified on the first date of testing, and IFM 63420, a resistant isolate identified on the third date of testing, both from 1 patient (A); and IFM 63666, IFM 63768, and IFM 63772, all isolated from other patients in the same hospital (B). The results of repeated experiments are expressed as mean ± SD (error bars).

Figure 2. Total ergosterol content of azole-susceptible and azole-resistant Aspergillus fumigatus isolates in Japan. Ergosterol was quantified in the sets of IFM 60814, a susceptible isolate identified on the first date of testing, and IFM 63420, a resistant isolate identified on the third date of testing, both from 1 patient (A); and IFM 63666, IFM 63768, and IFM 63772, all isolated from other patients in the same hospital (B). The results of repeated experiments are expressed as mean ± SD (error bars). The significance of total ergosterol content was determined by the Student t-test (unpaired, unequal variance). A p value <0.05 was considered significant.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
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