Volume 24, Number 10—October 2018
Research
Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
Table 5
Characteristics of Aspergillus fumigatus isolates from different patients in Japan*
Isolate IFM no. | Hospital | MCFG MEC, mg/L | MIC, mg/L |
Gene with mutation |
STRs |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AMPH | ITCZ | VRCZ | PSCZ | cyp51A | hmg1 | erg6 | 3A | 3B | 3C | 4A | 4B | 4C | |||||
62140 | K | <0.015 | 2 | 4 | 8 | 2 | – | F261_del | A75S | 42 | 11 | 14 | 13 | 9 | 8 | ||
64258 | I | <0.015 | 1 | 4 | 8 | 4 | – | F390Y | V206A | 26 | 14 | 17 | 5 | 11 | 10 | ||
64303 | T | <0.015 | 2 | 2 | 8 | – | – | – | – | 34 | 18 | 22 | 10 | 11 | 11 | ||
63666 | C | <0.015 | 1 | 1 | 2 | 1 | – | – | – | 29 | 13 | 15 | 10 | 9 | 5 | ||
63768 | C | <0.015 | 1 | 8 | >8 | 8 | – | S269Y | – | 29 | 13 | 15 | 10 | 9 | 5 | ||
63772 | C | <0.015 | 1 | 2 | 4 | 8 | – | – | – | 29 | 13 | 15 | 10 | 9 | 5 |
*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; PSCZ, posaconazole; STRs, short tandem repeats; VRCZ, voriconazole; –, no mutation.
1These authors contributed equally to this article.