Table 5

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara¹, Teppei Arai¹, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe

, and Katsuhiko Kamei

Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Characteristics of Aspergillus fumigatus isolates from different patients in Japan*

Isolate IFM no.	Hospital	MCFG MEC, mg/L	MIC, mg/L				Gene with mutation			STRs
Isolate IFM no.	Hospital	MCFG MEC, mg/L	AMPH	ITCZ	VRCZ	PSCZ	cyp51A	hmg1	erg6	3A	3B	3C	4A	4B	4C
62140	K	<0.015	2	4	8	2	–	F261_del	A75S	42	11	14	13	9	8
64258	I	<0.015	1	4	8	4	–	F390Y	V206A	26	14	17	5	11	10
64303	T	<0.015	2	2	8	–	–	–	–	34	18	22	10	11	11
63666	C	<0.015	1	1	2	1	–	–	–	29	13	15	10	9	5
63768	C	<0.015	1	8	>8	8	–	S269Y	–	29	13	15	10	9	5
63772	C	<0.015	1	2	4	8	–	–	–	29	13	15	10	9	5

*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; PSCZ, posaconazole; STRs, short tandem repeats; VRCZ, voriconazole; –, no mutation.

Main Article

¹These authors contributed equally to this article.

Page created: September 16, 2018

Page updated: September 16, 2018

Page reviewed: September 16, 2018

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