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Volume 24, Number 10—October 2018
Research

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira WatanabeComments to Author , and Katsuhiko Kamei
Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Table 5

Characteristics of Aspergillus fumigatus isolates from different patients in Japan*

Isolate IFM no. Hospital MCFG MEC, mg/L MIC, mg/L
 Gene with mutation
 STRs
AMPH ITCZ VRCZ PSCZ cyp51A hmg1 erg6 3A 3B 3C 4A 4B 4C
62140 K <0.015 2 4 8 2 – F261_del A75S 42 11 14 13 9 8
64258 I <0.015 1 4 8 4 – F390Y V206A 26 14 17 5 11 10
64303 T <0.015 2 2 8 – – – – 34 18 22 10 11 11
63666 C <0.015 1 1 2 1 – – – 29 13 15 10 9 5
63768 C <0.015 1 8 >8 8 – S269Y – 29 13 15 10 9 5
63772 C <0.015 1 2 4 8 – – – 29 13 15 10 9 5

*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; PSCZ, posaconazole; STRs, short tandem repeats; VRCZ, voriconazole; –, no mutation.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
Page reviewed: September 16, 2018
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