Volume 24, Number 10—October 2018
Research
Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe
, and Katsuhiko Kamei
, and Katsuhiko Kamei
Table 2
Characteristics of Aspergillus fumigatus isolates from a single patient in Japan*
| Isolate IFM no. | Date isolated (isolate set) | MCFG MEC, mg/L | MIC, mg/L |
Gene with mutation |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AMPH | ITCZ | VRCZ | PSCZ | Cyp51 | Hmg1 | Erg6 | ||||
| 60814 |
2001 Sep (1st) |
<0.015 |
0.5 |
0.5 |
0.5 |
1 |
– |
– |
– |
|
| 62916 |
2014 Sep (2nd) |
<0.015 |
0.5 |
>8 |
>8 |
8 |
G448S |
S269F |
E49K |
|
| 63240 | 2014 Nov (3rd) | <0.015 | 1 | >8 | >8 | 4 | – | S269F | A350T | |
| 63241 | <0.015 | 0.5 | >8 | >8 | 8 | – | S269F | A350T | ||
| 63242 | <0.015 | 1 | >8 | >8 | 8 | – | S269F | A350T | ||
| 63243 |
<0.015 |
1 |
>8 |
>8 |
8 |
– |
S269F |
A350T |
||
| 63248 | Jan 2015 (4th) | ND | ND | ND | ND | ND | – | S269F | E49K | |
| 63249 |
<0.015 |
1 |
4 |
8 |
8 |
G448S |
S269F |
E49K |
||
| 63537 |
2015 Jul (5th) |
<0.015 |
1 |
>8 |
8 |
8 |
– |
S269F |
A350T |
|
| 63594 | 2015 Sep (6th) | <0.015 | 1 | >8 | >8 | 8 | – | S269F | A350T | |
| 63595 | <0.015 | 1 | >8 | >8 | >8 | G448S | S269F | E49K | ||
| 63596 |
<0.015 |
1 |
>8 |
>8 |
8 |
– |
S269F |
A350T |
||
| 63711 | 2015 Dec (7th) | ND | ND | ND | ND | ND | – | S269F | E49K | |
| 63712 | ND | ND | ND | ND | ND | G448S | S269F | E49K | ||
| 63713 | ND | ND | ND | ND | ND | G448S | S269F | E49K | ||
| 63714 |
<0.015 |
1 |
>8 |
8 |
4 |
– |
S269F |
E49K |
||
| 64138 | 2016 Apr (8th) |
ND | ND | ND | ND | ND | – | S269F | E49K | |
| 64139 |
ND |
ND |
ND |
ND |
ND |
G448S |
S269F |
E49K |
||
| 64173 | 2016 May (9th) | <0.015 | 0.5 | >8 | 8 | 4 | – | S269F | A350T | |
*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; ND, not determined; PSCZ, posaconazole; VRCZ, voriconazole; –, no mutation.
1These authors contributed equally to this article.
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Page updated: September 16, 2018
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