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Volume 24, Number 10—October 2018
Research

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira WatanabeComments to Author , and Katsuhiko Kamei
Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Table 3

Characteristics of azole-susceptible isolates of Aspergillus fumigatus in Japan*

Isolate IFM no.
MCFG MEC, mg/L
MIC, mg/L

Gene with mutation

Short tandem repeats
AMPH
ITCZ
VRCZ
hmg1
erg6
3A
3B
3C
4A
4B
4C
49435 <0.015 1 0.25 0.25 52 17 20 10 11 11
50268 <0.015 0.5 0.25 0.125 14 10 11 13 9 10
50669 <0.015 1 0.5 0.25 12 18 20 16 9 5
50999 <0.015 1 0.5 0.5 33 12 37 11 9 5
51748 <0.015 0.5 0.125 0.125 26 11 29 25 10 8
51977 <0.015 1 0.25 0.25 25 9 7 12 11 17
57130 <0.015 1 0.25 0.125 47 21 19 10 11 5
58402 <0.015 1 0.5 0.5 27 10 5 9 9 5
60065 <0.015 1 1 0.5 15 17 17 17 16 10
60516 <0.015 1 1 1 22 11 7 16 11 8
60901 <0.015 1 0.5 0.5 H564Y 23 28 21 8 11 10
61572 <0.015 1 0.5 0.5 59 19 7 10 14 8
61960 <0.015 1 0.5 0.5 27 11 35 10 9 10
62674 <0.015 1 1 2 35 10 14 16 10 10
62709 <0.015 1 0.5 0.5 38 18 7 10 14 9
62821 <0.015 1 0.5 0.25 37 14 7 10 11 10

*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, Micafungin; MEC, minimal effective concentration; VRCZ, voriconazole; –, no mutation.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
Page reviewed: September 16, 2018
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