Table 3

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara¹, Teppei Arai¹, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe

, and Katsuhiko Kamei

Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Characteristics of azole-susceptible isolates of Aspergillus fumigatus in Japan*

Isolate IFM no.	MCFG MEC, mg/L	MIC, mg/L			Gene with mutation		Short tandem repeats
Isolate IFM no.	MCFG MEC, mg/L	AMPH	ITCZ	VRCZ	hmg1	erg6	3A	3B	3C	4A	4B	4C
49435	<0.015	1	0.25	0.25	–	–	52	17	20	10	11	11
50268	<0.015	0.5	0.25	0.125	–	–	14	10	11	13	9	10
50669	<0.015	1	0.5	0.25	–	–	12	18	20	16	9	5
50999	<0.015	1	0.5	0.5	–	–	33	12	37	11	9	5
51748	<0.015	0.5	0.125	0.125	–	–	26	11	29	25	10	8
51977	<0.015	1	0.25	0.25	–	–	25	9	7	12	11	17
57130	<0.015	1	0.25	0.125	–	–	47	21	19	10	11	5
58402	<0.015	1	0.5	0.5	–	–	27	10	5	9	9	5
60065	<0.015	1	1	0.5	–	–	15	17	17	17	16	10
60516	<0.015	1	1	1	–	–	22	11	7	16	11	8
60901	<0.015	1	0.5	0.5	H564Y	–	23	28	21	8	11	10
61572	<0.015	1	0.5	0.5	–	–	59	19	7	10	14	8
61960	<0.015	1	0.5	0.5	–	–	27	11	35	10	9	10
62674	<0.015	1	1	2	–	–	35	10	14	16	10	10
62709	<0.015	1	0.5	0.5	–	–	38	18	7	10	14	9
62821	<0.015	1	0.5	0.25	–	–	37	14	7	10	11	10

*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, Micafungin; MEC, minimal effective concentration; VRCZ, voriconazole; –, no mutation.

Main Article

¹These authors contributed equally to this article.

Page created: September 16, 2018

Page updated: September 16, 2018

Page reviewed: September 16, 2018

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