Volume 24, Number 10—October 2018
Research
Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe
, and Katsuhiko Kamei
, and Katsuhiko Kamei
Table 3
Characteristics of azole-susceptible isolates of Aspergillus fumigatus in Japan*
| Isolate IFM no. |
MCFG MEC, mg/L |
MIC, mg/L |
Gene with mutation |
Short tandem repeats |
||||||||||
| AMPH |
ITCZ |
VRCZ |
hmg1 |
erg6 |
3A |
3B |
3C |
4A |
4B |
4C |
||||
| 49435 | <0.015 | 1 | 0.25 | 0.25 | – | – | 52 | 17 | 20 | 10 | 11 | 11 | ||
| 50268 | <0.015 | 0.5 | 0.25 | 0.125 | – | – | 14 | 10 | 11 | 13 | 9 | 10 | ||
| 50669 | <0.015 | 1 | 0.5 | 0.25 | – | – | 12 | 18 | 20 | 16 | 9 | 5 | ||
| 50999 | <0.015 | 1 | 0.5 | 0.5 | – | – | 33 | 12 | 37 | 11 | 9 | 5 | ||
| 51748 | <0.015 | 0.5 | 0.125 | 0.125 | – | – | 26 | 11 | 29 | 25 | 10 | 8 | ||
| 51977 | <0.015 | 1 | 0.25 | 0.25 | – | – | 25 | 9 | 7 | 12 | 11 | 17 | ||
| 57130 | <0.015 | 1 | 0.25 | 0.125 | – | – | 47 | 21 | 19 | 10 | 11 | 5 | ||
| 58402 | <0.015 | 1 | 0.5 | 0.5 | – | – | 27 | 10 | 5 | 9 | 9 | 5 | ||
| 60065 | <0.015 | 1 | 1 | 0.5 | – | – | 15 | 17 | 17 | 17 | 16 | 10 | ||
| 60516 | <0.015 | 1 | 1 | 1 | – | – | 22 | 11 | 7 | 16 | 11 | 8 | ||
| 60901 | <0.015 | 1 | 0.5 | 0.5 | H564Y | – | 23 | 28 | 21 | 8 | 11 | 10 | ||
| 61572 | <0.015 | 1 | 0.5 | 0.5 | – | – | 59 | 19 | 7 | 10 | 14 | 8 | ||
| 61960 | <0.015 | 1 | 0.5 | 0.5 | – | – | 27 | 11 | 35 | 10 | 9 | 10 | ||
| 62674 | <0.015 | 1 | 1 | 2 | – | – | 35 | 10 | 14 | 16 | 10 | 10 | ||
| 62709 | <0.015 | 1 | 0.5 | 0.5 | – | – | 38 | 18 | 7 | 10 | 14 | 9 | ||
| 62821 | <0.015 | 1 | 0.5 | 0.25 | – | – | 37 | 14 | 7 | 10 | 11 | 10 | ||
*AMPH, amphotericin B; IFM, Institute of Food Microbiology (now Medical Mycology Research Center), Chiba University, Chiba City, Japan; ITCZ, itraconazole; MCFG, Micafungin; MEC, minimal effective concentration; VRCZ, voriconazole; –, no mutation.
1These authors contributed equally to this article.
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