Volume 24, Number 10—October 2018
Research
Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
Table 4
Strain | Genotype | MCFG MEC, mg/L | MIC, mg/L |
||||
---|---|---|---|---|---|---|---|
AMPH | ITCZ | VRCZ | MCZ | PSCZ | |||
1st+erg6WT | cyp51A, erg6, +erg6WT, hmg1 | <0.015 | 2 | 1 | 1–2 | 2 | 1–4 |
1st+erg6A350T | cyp51A, erg6, +erg6A350T, hmg1 | <0.015 | 2 | 1 | 0.5–1 | 2 | 4 |
1st+hmg1WT | cyp51A, erg6, hmg1, +hmg1WT | <0.015 | 2 | 1 | 1 | 2 | 1–4 |
1st+hmg1S269F | cyp51A, erg6, hmg1, +hmg1S269F | <0.015 | 1–2 | 0.5–1 | 0.5 | 1–2 | 2–4 |
1st+cyp51AWT | cyp51A, +cyp51AWT, erg6, hmg1 | <0.015 | 1–2 | 1 | 1–2 | 2–4 | 0.25–4 |
1st+cyp51AG448S | cyp51A, +cyp51AG448S, erg6, hmg1 | <0.015 | 1–2 | 4 | >8 | 4 | 4 |
*AMPH, amphotericin B; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; MCZ, miconazole; ND, not determined; PSCZ, posaconazole; STR, short tandem repeats; VRCZ, voriconazole.
1These authors contributed equally to this article.
Page created: September 16, 2018
Page updated: September 16, 2018
Page reviewed: September 16, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.