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Volume 24, Number 10—October 2018

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira WatanabeComments to Author , and Katsuhiko Kamei
Author affiliations: University of Tsukuba, Tsukuba, Japan (D. Hagiwara); Chiba University, Chiba City, Japan (D. Hagiwara, T. Arai, H. Takahashi, Y. Kusuya, A. Watanabe, K. Kamei)

Main Article

Table 4

Antifungal susceptibility test of mutants of erg6 and hmg1 from Aspergillus fumigatus isolates in Japan by transformation

Strain Genotype MCFG MEC, mg/L MIC, mg/L
1st+erg6WT cyp51A, erg6, +erg6WT, hmg1 <0.015 2 1 1–2 2 1–4
1st+erg6A350T cyp51A, erg6, +erg6A350T, hmg1 <0.015 2 1 0.5–1 2 4
1st+hmg1WT cyp51A, erg6, hmg1, +hmg1WT <0.015 2 1 1 2 1–4
1st+hmg1S269F cyp51A, erg6, hmg1, +hmg1S269F <0.015 1–2 0.5–1 0.5 1–2 2–4
1st+cyp51AWT cyp51A, +cyp51AWT, erg6, hmg1 <0.015 1–2 1 1–2 2–4 0.25–4
1st+cyp51AG448S cyp51A, +cyp51AG448S, erg6, hmg1 <0.015 1–2 4 >8 4 4

*AMPH, amphotericin B; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; MCZ, miconazole; ND, not determined; PSCZ, posaconazole; STR, short tandem repeats; VRCZ, voriconazole.

Main Article

1These authors contributed equally to this article.

Page created: September 16, 2018
Page updated: September 16, 2018
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