Volume 24, Number 10—October 2018
Research
Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase
Daisuke Hagiwara1, Teppei Arai1, Hiroki Takahashi, Yoko Kusuya, Akira Watanabe
, and Katsuhiko Kamei
, and Katsuhiko Kamei
Table 4
Antifungal susceptibility test of mutants of erg6 and hmg1 from Aspergillus fumigatus isolates in Japan by transformation
| Strain | Genotype | MCFG MEC, mg/L | MIC, mg/L |
||||
|---|---|---|---|---|---|---|---|
| AMPH | ITCZ | VRCZ | MCZ | PSCZ | |||
| 1st+erg6WT | cyp51A, erg6, +erg6WT, hmg1 | <0.015 | 2 | 1 | 1–2 | 2 | 1–4 |
| 1st+erg6A350T | cyp51A, erg6, +erg6A350T, hmg1 | <0.015 | 2 | 1 | 0.5–1 | 2 | 4 |
| 1st+hmg1WT | cyp51A, erg6, hmg1, +hmg1WT | <0.015 | 2 | 1 | 1 | 2 | 1–4 |
| 1st+hmg1S269F | cyp51A, erg6, hmg1, +hmg1S269F | <0.015 | 1–2 | 0.5–1 | 0.5 | 1–2 | 2–4 |
| 1st+cyp51AWT | cyp51A, +cyp51AWT, erg6, hmg1 | <0.015 | 1–2 | 1 | 1–2 | 2–4 | 0.25–4 |
| 1st+cyp51AG448S | cyp51A, +cyp51AG448S, erg6, hmg1 | <0.015 | 1–2 | 4 | >8 | 4 | 4 |
*AMPH, amphotericin B; ITCZ, itraconazole; MCFG, micafungin; MEC, minimal effective concentration; MCZ, miconazole; ND, not determined; PSCZ, posaconazole; STR, short tandem repeats; VRCZ, voriconazole.
1These authors contributed equally to this article.
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