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Volume 29, Number 2—February 2023
Research

Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland

Julianna L. Sun, Sehun Kim, Jenna Crowell, Bailey K. Webster, Emma K. Raisley, Diana C. Lowe, Jifeng Bian, Sirkka-Liisa Korpenfelt, Sylvie L. Benestad, and Glenn C. TellingComments to Author 
Author affiliations: Colorado State University, Fort Collins, Colorado, USA (J.L. Sun, S. Kim, J. Crowell, B.K. Webster, E.K. Raisley, D.C. Lowe, J. Bian, G.C. Telling); Finnish Food Authority, Helsinki, Finland (S.-L. Korpenfelt); Norwegian Veterinary Institute, Ås, Norway (S.L. Benestad)

Main Article

Figure 4

Lesion profiling in GtQ mice infected with Finland and Norway moose chronic wasting disease (CWD) isolates. Lesion profiles in groups of GtQ mice (CWD-susceptible gene-targeted mice in which the prion protein coding sequence was replaced with one encoding glutamine at codon 226) infected with M-F1 (magenta symbols) and Norway moose isolate M-NO1 (green symbols). For M-F1, open circles and solid lines depict primary passage; dotted circles and dashed lines depict second passage. Data points represent the mean +SEM of >5 GtQ mice per group. Brain-scoring areas: medulla (1), cerebellum (2), superior colliculus (3), hypothalamus (4), thalamus (5), hippocampus (6), septum (7), retrosplenial and adjacent motor cortex (8), and cingulate and adjacent motor cortex (9). M-F1, Finland moose 1; M-NO1, Norway moose 1.

Figure 4. Lesion profiling in GtQ mice infected with Finland and Norway moose chronic wasting disease (CWD) isolates. Lesion profiles in groups of GtQ mice (CWD-susceptible gene-targeted mice in which the prion protein coding sequence was replaced with one encoding glutamine at codon 226) infected with M-F1 (magenta symbols) and Norway moose isolate M-NO1 (green symbols). For M-F1, open circles and solid lines depict primary passage; dotted circles and dashed lines depict second passage. Data points represent the mean +SEM of >5 GtQ mice per group. Brain-scoring areas: medulla (1), cerebellum (2), superior colliculus (3), hypothalamus (4), thalamus (5), hippocampus (6), septum (7), retrosplenial and adjacent motor cortex (8), and cingulate and adjacent motor cortex (9). M-F1, Finland moose 1; M-NO1, Norway moose 1.

Main Article

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Page updated: January 21, 2023
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