Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland
Julianna L. Sun, Sehun Kim, Jenna Crowell, Bailey K. Webster, Emma K. Raisley, Diana C. Lowe, Jifeng Bian, Sirkka-Liisa Korpenfelt, Sylvie L. Benestad, and Glenn C. Telling
Author affiliations: Colorado State University, Fort Collins, Colorado, USA (J.L. Sun, S. Kim, J. Crowell, B.K. Webster, E.K. Raisley, D.C. Lowe, J. Bian, G.C. Telling); Finnish Food Authority, Helsinki, Finland (S.-L. Korpenfelt); Norwegian Veterinary Institute, Ås, Norway (S.L. Benestad)
Figure 5. Immunohistochemical analyses of disease-associated prion protein (PrP) in the CNS of transgenic (Tg) and gene-targeted (Gt) mice infected with Finland, Norwway, and North America chronic wasting disease (CWD) isolates. A) GtQ mice (CWD-susceptible Gt mice in which the PrP coding sequence was replaced with one encoding glutamine at codon 226) infected with CWD isolate from Finland moose 1 (MF-1). B) TgE mice (Tg mice expressing cervid PrP with glutamate at residue 226) infected with M-F1. C) GtQ mice infected with CWD isolate from Norway moose 1 (M-NO1). D) GtQ mice infected with CWD isolate from US moose 1. Arrows in panels A, B, and C indicate small puncta of PrP. Immunohistochemistry sections were stained with fragment antigen binding D18. Original magnification ×10.
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