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Volume 29, Number 2—February 2023
Research

Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland

Julianna L. Sun, Sehun Kim, Jenna Crowell, Bailey K. Webster, Emma K. Raisley, Diana C. Lowe, Jifeng Bian, Sirkka-Liisa Korpenfelt, Sylvie L. Benestad, and Glenn C. TellingComments to Author 
Author affiliations: Colorado State University, Fort Collins, Colorado, USA (J.L. Sun, S. Kim, J. Crowell, B.K. Webster, E.K. Raisley, D.C. Lowe, J. Bian, G.C. Telling); Finnish Food Authority, Helsinki, Finland (S.-L. Korpenfelt); Norwegian Veterinary Institute, Ås, Norway (S.L. Benestad)

Main Article

Table 1

Susceptibility of gene-targeted mice to intracerebral challenges with CWD prions from Finland and Norwway moose*

Inoculum GtQ GtE
M-F1 CNS 259 +19 (10/11) >545 (0/9)
M-NO1 440 +13 (13/13)
M-NO2 486 +34 (13/13)
M-NO3 451 +33 (4/4)
M-F1 LRS >545 (0/10) >550 (0/6)

*Time to disease onset (incubation time) is expressed as the mean number of days after which inoculated mice first showed ultimately progressive signs of neurologic disease + SD. Parentheses include the numbers of diseased mice/number of inoculated mice. Incubation times of Norway moose CWD prions have been described previously (27). GtE, CWD-susceptible gene-targeted mice in which the prion protein coding sequence was replaced with one encoding glutamate at codon 226; GtQ, CWD-susceptible gene-targeted mice in which the prion protein coding sequence was replaced with one encoding glutamine at codon 226; M-F1 CNS, Finland moose 1 (central nervous system); M-F1 LRS, Finland moose 1 (lymphoreticular system); M-NO1, Norway moose 1; M-NO2, Norway moose 2; M-NO3, Norway moose 3.

Main Article

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