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Volume 29, Number 2—February 2023

Novel Prion Strain as Cause of Chronic Wasting Disease in a Moose, Finland

Julianna L. Sun, Sehun Kim, Jenna Crowell, Bailey K. Webster, Emma K. Raisley, Diana C. Lowe, Jifeng Bian, Sirkka-Liisa Korpenfelt, Sylvie L. Benestad, and Glenn C. TellingComments to Author 
Author affiliations: Colorado State University, Fort Collins, Colorado, USA (J.L. Sun, S. Kim, J. Crowell, B.K. Webster, E.K. Raisley, D.C. Lowe, J. Bian, G.C. Telling); Finnish Food Authority, Helsinki, Finland (S.-L. Korpenfelt); Norwegian Veterinary Institute, Ås, Norway (S.L. Benestad)

Main Article

Table 2

Susceptibility of gene-targeted mice to intracerebral challenges with serial passages of Finnish and Norwegian moose CWD prions*

Inoculum GtQ GtE
GtQ (M-F1) brain 1 228 +3 (10/10) >469 +17 (4/7)
GtQ (M-F1) brain 2 223 +4 (9/9) >507 (0/5)
GtQ (M-NO1) 281 +24 (5/5)
GtQ (M-NO2) 541 + 5 (5/7)

*Time to disease onset (incubation time) is expressed as the mean number of days after which inoculated mice first showed ultimately progressive signs of neurologic disease +SD. Parentheses include the numbers of diseased mice/number of inoculated mice. Incubation times of Norway moose CWD prions have been described previously (27). CWD, chronic wasting disease; GtE, CWD-susceptible gene-targeted mice in which the prion protein coding sequence was replaced with one encoding glutamate at codon 226; GtQ, CWD-susceptible gene-targeted mice in which the prion protein coding sequence was replaced with one encoding glutamine at codon 226; M-F1, Finland moose 1; M-NO1, Norway moose 1; M-NO2, Norway moose 2.

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