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Volume 29, Number 4—April 2023
Research

Adeno-Associated Virus 2 and Human Adenovirus F41 in Wastewater during Outbreak of Severe Acute Hepatitis in Children, Ireland

Niamh A. Martin, Gabriel Gonzalez, Liam J. Reynolds, Charlene Bennett, Christine Campbell, Tristan M. Nolan, Alannah Byrne, Sanne Fennema, Niamh Holohan, Sailusha Ratnam Kuntamukkula, Natasha Sarwar, Laura Sala-Comorera, Jonathan Dean, Jose Maria Urtasun-Elizari, Daniel Hare, Emer Liddy, Eadaoin Joyce, John J. O’Sullivan, John M. Cuddihy, Angeline M. McIntyre, Eve P. Robinson, Darren Dahly, Nicola F. Fletcher, Suzanne Cotter, Emer Fitzpatrick, Michael J. Carr, Cillian F. De Gascun, and Wim G. MeijerComments to Author 
Author affiliations: University College Dublin, Dublin, Ireland (N.A. Martin, G. Gonzalez, L.J. Reynolds, C. Bennett, C. Campbell, T.M. Nolan, A. Byrne, S. Fennema, N. Holohan, S.R. Kuntamukkula, N. Sarwar, L. Sala-Comorera, J. Dean, J.M. Urtasun-Elizari, D. Hare, J.J. O’Sullivan, N.F. Fletcher, M.J. Carr, C.F. De Gascun, W.G. Meijer); Hokkaido University, Sapporo, Japan (G. Gonzalez, M.J. Carr); Health Protection Surveillance Centre, Dublin, Ireland (E. Liddy, J.M. Cuddihy, A.M McIntyre, E.P. Robinson, S. Cotter); Irish Water, Dublin, Ireland (E. Joyce); University College Cork, Cork, Ireland (D. Dahly); Children’s Health Ireland at Crumlin, Crumlin, Ireland (E. Fitzpatrick)

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Figure 3

Hexon fragment sequencing for HAdV typing in wastewater, Ireland. A) Diagram of the average nucleotide evolutionary distance among all known HAdV types across the hexon-coding gene. The positions of the variable loops 1 and 2 have been annotated relative to positions in HAdV-F41. The amplicon target used for typing is annotated in blue. B) Type classification of reads in each sample, shown as the percentage of the total of aligned reads per sample, shown at the top of each bar. HAdV, human adenovirus.

Figure 3. Hexon fragment sequencing for HAdV typing in wastewater, Ireland. A) Diagram of the average nucleotide evolutionary distance among all known HAdV types across the hexon-coding gene. The positions of the variable loops 1 and 2 have been annotated relative to positions in HAdV-F41. The amplicon target used for typing is annotated in blue. B) Type classification of reads in each sample, shown as the percentage of the total of aligned reads per sample, shown at the top of each bar. HAdV, human adenovirus.

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Page created: January 24, 2023
Page updated: March 20, 2023
Page reviewed: March 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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