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Volume 30, Number 7—July 2024
Research

Sialic Acid Receptor Specificity in Mammary Gland of Dairy Cattle Infected with Highly Pathogenic Avian Influenza A(H5N1) Virus

Rahul K. Nelli1Comments to Author , Tyler A. Harm1, Chris Siepker1, Jennifer M. Groeltz-Thrush, Brianna Jones, Ning-Chieh Twu, Ariel S. Nenninger, Drew R. Magstadt, Eric R. Burrough, Pablo E. Piñeyro, Marta Mainenti, Silvia Carnaccini, Paul J. Plummer, and Todd M. BellComments to Author 
Author affiliations: Iowa State University College of Veterinary Medicine, Ames, Iowa, USA (R.K. Nelli, T.A. Harm, C. Siepker, J.M. Groeltz-Thrush, B. Jones, N.-C. Twu, A.S. Nenninger, D.R. Magstadt, E.R. Burrough, P.E. Piñeyro, M. Mainenti, P.J. Plummer, T.M. Bell); University of Georgia, Athens, Georgia, USA (S. Carnaccini)

Main Article

Table

Distribution of α2,3 and α2,6 receptors with influenza A virus nucleoprotein in the respiratory tract and mammary gland of US dairy cattle naturally infected with highly pathogenic avian influenza A(H5N1) virus*

Site MAL-I MAL-II SNA IAV-Np
Respiratory tract
Tracheal epithelium + (mem, goblet) + (mem, goblet) +/− (goblet) –
Bronchial epithelium + (mem, goblet) + (mem, goblet) – –
Bronchiolar epithelium + (mem) + (mem) – –
Pneumocytes, alveolus
 + (mem)
 + (mem)
 –
 –
Mammary gland
Glandular epithelium – + (mem) + (mem) + (IN, IC)
Interlobular ductal epithelium – – + (mem) + (IN, IC)

*Goblet, goblet cells; IC, intracytoplasmic; IN, intranuclear; IAV-Np, influenza A virus nucleoprotein; MAL, Maackia amurensis lectin; mem, membranous; SNA, Sambucus nigra lectin; –, no labeling observed; +, positive labeling. †α2,3-gal-β (1–4) N-acetylglucosamine. ‡α2,3-gal-β (1–3) N-acetylgalactosamine. §α2,6-gal.

Main Article

1These first authors contributed equally to this article.

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Page updated: June 22, 2024
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