Figure 3. Histopathologic findings in reproductive tissues of strain 13/N guinea pigs with lethal disease after Lassa virus (LASV) strain Josiah infection in study of guinea pig model for LASV infection of reproductive tract and considerations for sexual and vertical transmission. Panels A–F depict samples from female guinea pigs; panels G–L depict samples from male guinea pigs. A) Ovary (25 days postinfection [dpi]) with moderate perivascular and interstitial inflammation (arrows). B) Oviduct (20 dpi) with focal interstitial inflammation and edema (asterisk) within the serosa. C) Uterus (23 dpi) with mild endometrial inflammation and edema (asterisk) and hemosiderin-laden macrophages (arrow). D) Uterus (25 dpi) with multifocal mononuclear inflammatory cells (arrow) forming partial cuffs around vessels in the myometrium. E) Uterine vessel (23 dpi) with mural infiltration by lymphocytes and plasma cells (arrow). F) Cervix (23 dpi) with multifocal, mild, perivascular inflammation (arrow). G) Epididymis (26 dpi) with moderate perivascular inflammation (asterisks). H) Epididymis (23 dpi) with multifocal interstitial inflammation around tubules (asterisk) and a vessel (arrow). I) Epididymis (26 dpi) with marked epididymitis with tubular dilation by inflammatory cells (arrow) and rupture, associated with sperm granuloma formation (asterisk). J) Epididymis (23 dpi) with marked epididymitis, with interstitial inflammation (arrows), and intratubular heterophils associated with rupture and granuloma formation (asterisk). K) Epididymis (26 dpi) with marked interstitial inflammation (arrow) and tubular epithelial necrosis with heterophils (asterisk). L) Prostate (23 dpi) with mild focal lymphocytic, perivascular inflammation (arrow). Hemotoxylin and eosin stain. Original magnifications ×20 (panels A, E, G, I, K), ×15 (panels B, H), and ×10 (panels C, D, F, J, L).