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Volume 31, Number 3—March 2025
Research

Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity

Valerie Le SageComments to Author , Bailee D. Werner, Grace A. Merrbach, Sarah E. Petnuch, Aoife K. O’Connell, Holly C. Simmons, Kevin R. McCarthy, Douglas S. Reed, Louise H. Moncla, Disha Bhavsar, Florian Krammer, Nicholas A. Crossland, Anita K. McElroy, W. Paul Duprex, and Seema S. Lakdawala
Author affiliation: Author affiliations: University of Pittsburgh, Pittsburgh, Pennsylvania, USA (V. Le Sage, B.D. Werner, G.A. Merrbach, S.E. Petnuch, H.C. Simmons, K.R. McCarthy, D.S. Reed, L.H. Moncla, A.K. McElroy, W.P. Duprex); Boston University, Boston, Massachusetts, USA (A.K. O’Connell, N.A. Crossland); Icahn School of Medicine at Mount Sinai, New York, New York, USA (D. Bhavsar, F. Krammer); Medical University of Vienna, Vienna, Austria (F. Krammer); Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA (N.A. Crossland); Emory University, Atlanta, Georgia, USA (S.S. Lakdawala)

Main Article

Figure 5

Hematoxylin and eosin–stained lymph node samples from a study of influenza A(H5N1) immune response among ferrets with pH1N1 immunity. Ferrets with no prior immunity (left panel) or pH1N1 (right panel) were infected with 104 50% tissue culture infectious dose of H5N1 strain A/dairy cattle/Texas/24-008749-001/2024(H5N1) and humanely euthanized 3 days postinfection. Dotted squares indicate areas that are with cortical lymphoid necrosis and depletion in tissues from ferrets with no prior immunity versus normal secondary germinal center in pH1N1-immune ferret. Scale bars indicate 100 mm. pH1N1, influenza A(H1N1)pdm09.

Figure 5. Hematoxylin and eosin–stained lymph node samples from a study of influenza A(H5N1) immune response among ferrets with pH1N1 immunity. Ferrets with no prior immunity (left panel) or pH1N1 (right panel) were infected with 104 50% tissue culture infectious dose of H5N1 strain A/dairy cattle/Texas/24-008749-001/2024(H5N1) and humanely euthanized 3 days postinfection. Dotted squares indicate areas that are with cortical lymphoid necrosis and depletion in tissues from ferrets with no prior immunity versus normal secondary germinal center in pH1N1-immune ferret. Scale bars indicate 100 mm. pH1N1, influenza A(H1N1)pdm09.

Main Article

Page created: January 21, 2025
Page updated: February 28, 2025
Page reviewed: February 28, 2025
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