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Volume 31, Number 3—March 2025
Research

Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity

Valerie Le SageComments to Author , Bailee D. Werner, Grace A. Merrbach, Sarah E. Petnuch, Aoife K. O’Connell, Holly C. Simmons, Kevin R. McCarthy, Douglas S. Reed, Louise H. Moncla, Disha Bhavsar, Florian Krammer, Nicholas A. Crossland, Anita K. McElroy, W. Paul Duprex, and Seema S. Lakdawala
Author affiliation: Author affiliations: University of Pittsburgh, Pittsburgh, Pennsylvania, USA (V. Le Sage, B.D. Werner, G.A. Merrbach, S.E. Petnuch, H.C. Simmons, K.R. McCarthy, D.S. Reed, L.H. Moncla, A.K. McElroy, W.P. Duprex); Boston University, Boston, Massachusetts, USA (A.K. O’Connell, N.A. Crossland); Icahn School of Medicine at Mount Sinai, New York, New York, USA (D. Bhavsar, F. Krammer); Medical University of Vienna, Vienna, Austria (F. Krammer); Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA (N.A. Crossland); Emory University, Atlanta, Georgia, USA (S.S. Lakdawala)

Main Article

Table

Serologic testing from a study of influenza A(H5N1) immune response among ferrets with pH1N1 immunity*

Ferret no. Euthanasia, dpi Microneutralization titers
H5N1
 pH1N1
0 dpi At euthanasia 0 dpi At euthanasia
Naive group
1 3 <20 <20 ND ND
2 3 <20 <20 ND ND
3 3 <20 <20 ND ND
4 4 <20 <20 ND ND
5
 6
 <20
 <20
ND
 ND
pH1N1-immune group
1 3 <20 <20 905 1,016
2 3 <20 <20 508 320
3 3 <20 <20 2,032 508
4 14 <20 20 2,560 2,032
5 14 <20 80 640 2,032

*A/dairy cattle/Texas/24-008749-001/2024(H5N1) strain (GISAID accession no. EPI_ISL_19014384) was used for H5N1 inoculation. dpi, days postinoculation; ND, not done; pH1N1, influenza A(H1N1)pdm09.

Main Article

Page created: January 21, 2025
Page updated: February 28, 2025
Page reviewed: February 28, 2025
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