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Volume 31, Number 7—July 2025

Research

Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis

Ellie J. PutzComments to Author , Claire B. Andreasen, Paola Boggiatto, Mitchell V. Palmer, Luis G.V. Fernandes, Bienvenido W. Tibbs-Cortes, Judith A. Stasko, Camila Hamond, Steven C. Olsen, and Jarlath E. Nally
Author affiliation: National Animal Disease Center, US Department of Agriculture Agricultural Research Service, Ames, Iowa, USA (E.J. Putz, P. Boggiatto, M.V. Palmer, L.G.V. Fernandes, B.W. Tibbs-Cortes, J.A. Stasko, S.C. Olsen, J.E. Nally); Iowa State University College of Veterinary Medicine, Ames (C.B. Andreasen); National Veterinary Services Laboratories, US Department of Agriculture Animal and Plant Health Inspection Service, Ames (C. Hamond)

Main Article

Figure 5

Concentrations of foamy macrophages per 100 leukocytes in whole blood smears from male and female Peromyscus deer mice in study of the species as rodent model of acute leptospirosis. Concentrations of foamy macrophages are shown for acute disease male, acute disease female, and NC female mice taken when acute male mice reached endpoint for challenge with Leptospira interrogans strain LAD1 (A) or L. borgpetersenii strain LR131 (B). Error bars depict SEs. Asterisk denotes a significant difference (p<0.05) from media alone and negative control groups, whereas pound sign denotes a significant difference (p<0.05) between male and female groups. NC, nonclinical.

Figure 5. Concentrations of foamy macrophages per 100 leukocytes in whole blood smears from male and female Peromyscus deer mice in study of the species as rodent model of acute leptospirosis. Concentrations of foamy macrophages are shown for acute disease male, acute disease female, and NC female mice taken when acute male mice reached endpoint for challenge with Leptospira interrogans strain LAD1 (A) or L. borgpetersenii strain LR131 (B). Error bars depict SEs. Asterisk denotes a significant difference (p<0.05) from media alone and negative control groups, whereas pound sign denotes a significant difference (p<0.05) between male and female groups. NC, nonclinical.

Main Article

Page created: May 22, 2025
Page updated: June 12, 2025
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