Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 7—July 2025

Research

Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis

Ellie J. PutzComments to Author , Claire B. Andreasen, Paola Boggiatto, Mitchell V. Palmer, Luis G.V. Fernandes, Bienvenido W. Tibbs-Cortes, Judith A. Stasko, Camila Hamond, Steven C. Olsen, and Jarlath E. Nally
Author affiliation: National Animal Disease Center, US Department of Agriculture Agricultural Research Service, Ames, Iowa, USA (E.J. Putz, P. Boggiatto, M.V. Palmer, L.G.V. Fernandes, B.W. Tibbs-Cortes, J.A. Stasko, S.C. Olsen, J.E. Nally); Iowa State University College of Veterinary Medicine, Ames (C.B. Andreasen); National Veterinary Services Laboratories, US Department of Agriculture Animal and Plant Health Inspection Service, Ames (C. Hamond)

Main Article

Table

Manual differential cell counts on Giemsa-stained whole blood smears in study of Peromyscus species deer mice as rodent model of acute leptospirosis*

Group Cells/100 leukocytes
Foamy macrophages Monocytes Neutrophils Lymphocytes Eosinophils and basophils
LR131 female 3.75 + 1.25† 3.08 + 0.54† 34.00 + 3.12† 58.2 + 3.40† 0.92 + 0.48
LR131 male 7.63 + 1.53† 4.13 + 0.66† 36.62 + 3.82† 50.4 + 4.17† 0.88 + 0.59
LR131 nonclinical female 0.33 + 2.50 1.33 + 1.07 47.33 + 6.24† 49.7 + 6.81† 1.33 + 0.96
LAD1 female 1.70 + 1.37 2.00 + 0.59 24.00 + 3.42 70.6 + 3.73† 1.70 + 0.53
LAD1 male 3.36 + 1.16† 2.86 + 0.50† 35.50 + 2.89† 55.1 + 3.15† 3.14 + 0.45†
LAD1 nonclinical female 0.50 + 2.17 1.75 + 0.93 26.50 + 5.41 68.2 + 5.90† 2.75 + 0.84†
HAN media 0.22 + 0.90 1.04 + 0.39 16.26 + 2.26 81.6 + 2.46 0.87 + 0.35
Negative 0.00 + 1.53 0.88 + 0.66 8.38 + 3.82 90.6 + 4.17 0.13 + 0.59

*Table shows the least square means of foamy macrophages, monocytes, neutrophils, lymphocytes, and combined eosinophils and basophils, with their respective SEs. †Denotes a significant difference (p<0.05) compared with HAN media controls.

Main Article

Page created: May 22, 2025
Page updated: June 12, 2025
Page reviewed: June 12, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external