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Volume 31, Number 7—July 2025

Research

Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis

Ellie J. PutzComments to Author , Claire B. Andreasen, Paola Boggiatto, Mitchell V. Palmer, Luis G.V. Fernandes, Bienvenido W. Tibbs-Cortes, Judith A. Stasko, Camila Hamond, Steven C. Olsen, and Jarlath E. Nally
Author affiliation: National Animal Disease Center, US Department of Agriculture Agricultural Research Service, Ames, Iowa, USA (E.J. Putz, P. Boggiatto, M.V. Palmer, L.G.V. Fernandes, B.W. Tibbs-Cortes, J.A. Stasko, S.C. Olsen, J.E. Nally); Iowa State University College of Veterinary Medicine, Ames (C.B. Andreasen); National Veterinary Services Laboratories, US Department of Agriculture Animal and Plant Health Inspection Service, Ames (C. Hamond)

Main Article

Figure 9

Genomic equivalent burden of calculated leptospires per gram of tissue between male and female Peromyscus deer mice in study of the species as rodent model of acute leptospirosis. Graphs show the PCR-calculated bacterial load in infected kidneys (A) and livers (B) from deer mice infected with strain LR131 Leptospira borgpetersenii or strain LAD1 L. interrogans, HAN media alone, and noninfected negative control. Groups shown consist of acute disease male mice, acute disease female mice, and NC female mice taken when acute male mice reached endpoint. Error bars depict SEs. Asterisk denotes a significant difference (p<0.05) from media alone and negative control groups, whereas pound sign denotes a significant difference (p<0.05) between male and female groups. NC, nonclinical.

Figure 9. Genomic equivalent burden of calculated leptospires per gram of tissue between male and female Peromyscus deer mice in study of the species as rodent model of acute leptospirosis. Graphs show the PCR-calculated bacterial load in infected kidneys (A) and livers (B) from deer mice infected with strain LR131 Leptospira borgpetersenii or strain LAD1 L. interrogans, HAN media alone, and noninfected negative control. Groups shown consist of acute disease male mice, acute disease female mice, and NC female mice taken when acute male mice reached endpoint. Error bars depict SEs. Asterisk denotes a significant difference (p<0.05) from media alone and negative control groups, whereas pound sign denotes a significant difference (p<0.05) between male and female groups. NC, nonclinical.

Main Article

Page created: May 22, 2025
Page updated: June 12, 2025
Page reviewed: June 12, 2025
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