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Volume 32, Number 8—August 2026

Research

Virulence of Burkholderia pseudomallei Strains from Western Hemisphere and Africa in Mice

Christopher P. Klimko, J. Matthew Meinig, Kevin D. Mlynek, Nathaniel O. Rill, Sergei S. Biryukov, Jennifer L. Dankmeyer, Annette M. Gray, Jennifer Chua, Stephanie A. Halasahoris, Michael L. Davies, Brian A. Smith, Carlos I. Rodriguez-Negron, Christopher T. Braun, Elsie E. Martinez, Jade L. Spencer, David N. Dyer, Ondraya M. Frick, Marjorie E. Torres, Mindy G. Elrod, Jay E. Gee, Christopher A. Gulvik, Zachary P. Weiner, Ju Qiu, Joel A. Bozue, David DeShazer, and Christopher K. CoteComments to Author 
Author affiliation: US Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA (C.P. Klimko, J.M. Meinig, K.D. Mlynek, N.O. Rill, S.S. Biryukov, J.L. Dankmeyer, A.M. Gray, J. Chua, S.A. Halasahoris, M.L. Davies, B.A. Smith, C.I. Rodriguez-Negron, C.T. Braun, E.E. Martinez, J.L. Spencer, D.N. Dyer, O.M. Frick, M.E. Torres, J. Qiu, J.A Bozue, D. DeShazer, C.K. Cote); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.G. Elrod, J.E. Gee, C.A. Gulvik, Z.P. Weiner)

Main Article

Table 1

Burkholderia pseudomallei Western Hemisphere and African strain panel used in study of virulence of B. pseudomallei in mice*

Strain, NCBI SRA accession nos. (reference) Location Travel history Clinical history Collection type
GHD1A, SRR28096053 and SRR28096054 (30)
 Ghana
 NA
 NA
 Environmental, ST2058 novel strain type grouped within a subclade that include isolates from Burkina Faso
BpNY2023b, SRR35239810 (NA)
 New York, USA
 Ghana
 27 years of age, woman, cutaneous lesion on scalp
 None
AZ1999, SRR9182277 and SRR9182846 (12)
 Arizona, USA
 El Salvador
 37 years of age, woman
 None
VEN1976, SRR5221036 (31)
Venezuela
 Unknown
 Unknown
 None
PB10007001, SRR5221028 (31)
 Arizona, USA
 Costa Rica
 Woman, boat propeller wound to left thigh
 None
IL2014, SRR5221014 (32)
 Illinois, USA
 Mexico
 59 years of age, woman, 4-day history of right-side, upper back, and anterior chest pain, dyspnea, and fevers. Diabetes mellitus, controlled HIV infection; cadaveric renal transplant recipient 13 months prior
 None
PR2013a, SRR5221018 (31)
 Puerto Rico, USA
 NA
 NA
 Environmental
GHC5E, SRR28096044 and SRR28096045 (30)
 Ghana
 NA
 NA
 Environmental, ST1749 similar Caribbean isolates
MS2020a, SRR23747754 (11)
 Mississippi, USA
 NA
 39 years of age, man, initial manifestation of acute respiratory distress and fever followed by multisystem organ failure. Admitted to intensive care unit with bilateral multilobar pneumonia and sepsis.
 None
TX2004, SRR5221034 (12) Texas, USA Cryptic 82 years of age, male, with chronic renal insufficiency, diabetes, and hypertension. Cutaneous lesion on right hand. Putative locally acquired

*NA, not available; NCBI SRA, National Center for Biotechnology Information Sequence Read Archive.

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