Volume 32, Number 8—August 2026
Research
Virulence of Burkholderia pseudomallei Strains from Western Hemisphere and Africa in Mice
Christopher P. Klimko, J. Matthew Meinig, Kevin D. Mlynek, Nathaniel O. Rill, Sergei S. Biryukov, Jennifer L. Dankmeyer, Annette M. Gray, Jennifer Chua, Stephanie A. Halasohoris, Michael L. Davies, Brian A. Smith, Carlos I. Rodriguez-Negron, Christopher T. Braun, Elsie E. Martinez, Jade L. Spencer, David N. Dyer, Ondraya M. Frick, Marjorie E. Torres, Mindy G. Elrod, Jay E. Gee, Christopher A. Gulvik, Zachary P. Weiner, Ju Qiu, Joel A. Bozue, David DeShazer, and Christopher K. Cote
Table 4
Bacterial count in survivors of select dose-groups of C57BL/6 mouse models in a study of Burkholderia pseudomallei virulence
| Strain | Inhaled dose | Organ | No. survivors | No. organs Infected | CFU/g, range |
|---|---|---|---|---|---|
| GHD1A |
1.71 × 101 | Lungs | 7 | 0 | 0 |
| Spleen | 7 | 0 | 0 | ||
| Brain | 7 | 1 | 9.26 × 10° | ||
| 1.68 × 102 | Lungs | 5 | 2 | 3.18 × 103–4.00 × 103 | |
| Spleen | 5 | 0 | 0 | ||
| Brain | 5 | 2 | 8.75 × 102–2.19 × 103 | ||
| 1.88 × 103 |
Lungs | 2 | 1 | 2.94 × 101 | |
| Spleen | 2 | 0 | 0 | ||
| Brain |
2 |
1 |
8.93 × 101 |
||
| BpNY2023b |
1.24 × 101 | Lungs | 8 | 0 | 0 |
| Spleen | 8 | 0 | 0 | ||
| Brain | 8 | 1 | 1.54 × 101 | ||
| 1.02 × 102 |
Lungs | 5 | 1 | 2.26 × 103 | |
| Spleen | 5 | 1 | 1.85 × 105 | ||
| Brain |
5 |
3 |
1.96 × 101–3.93 × 102 |
||
| AZ1999 |
1.29 × 102 | Lungs | 8 | 2 | 2.94 × 101–1.07 × 102 |
| Spleen | 8 | 0 | 0 | ||
| Brain | 8 | 6 | 1.00 × 101–1.75 × 103 | ||
| 8.22 × 102 |
Lungs | 5 | 2 | 3.33 × 101–1.45 × 102 | |
| Spleen | 5 | 0 | 0 | ||
| Brain |
5 |
5 |
1.31 × 102–6.57 × 102 |
||
| VEN1976 |
9.99 × 101 |
Lungs | 6 | 1 | 7.21 × 102 |
| Spleen | 6 | 0 | 0 | ||
| Brain |
6 |
1 |
1.44 × 103 |
||
| PB10007001 |
1.20 × 102 | Lungs | 6 | 1 | 4.09 × 102 |
| Spleen | 6 | 0 | 0 | ||
| Brain | 6 | 1 | 3.73 × 103 | ||
| 4.63 × 102 |
Lungs | 2 | 1 | 2.30 × 102 | |
| Spleen | 2 | 0 | 0 | ||
| Brain |
2 |
2 |
6.78 × 101–6.76 × 102 |
||
| IL2014 |
6.65 × 101 | Lungs | 9 | 1 | 1.07 × 104 |
| Spleen | 9 | 2 | 8.44 × 107–1.08 × 108 | ||
| Brain | 9 | 6 | 7.41 × 101–8.25 × 104 | ||
| 4.19 × 102 |
Lungs | 3 | 1 | 3.75 × 101 | |
| Spleen | 3 | 0 | 0 | ||
| Brain |
3 |
2 |
1.79 × 101–2.19 × 102 |
||
| PR2013a |
6.31 × 101 | Lungs | 8 | 1 | 4.41 × 101 |
| Spleen | 8 | 0 | 0 | ||
| Brain | 8 | 2 | 8.93 × 100–3.23 × 101 | ||
| 4.87 × 102 |
Lungs | 5 | 1 | 4.00 × 101 | |
| Spleen | 5 | 1 | 6.82 × 101 | ||
| Brain |
5 |
4 |
2.42 × 102–2.75 × 103 |
||
| GHC5E |
5.27 × 101 | Lungs | 7 | 1 | 1.85 × 102 |
| Spleen | 7 | 0 | 0 | ||
| Brain | 7 | 2 | 1.53 × 102–3.51 × 102 | ||
| 4.22 × 102 |
Lungs | 1 | 0 | 0 | |
| Spleen | 1 | 0 | 0 | ||
| Brain |
1 |
1 |
1.09 × 102 |
||
| MS2020a |
7.43 × 101 | Lungs | 3 | 0 | 0 |
| Spleen | 6 | 0 | 0 | ||
| Brain | 3 | 0 | 0 | ||
| 3.53 × 103 |
Lungs | 4 | 1 | Detected, unquantifiable because contaminated | |
| Spleen | 4 | 1 | Too numerous to count | ||
| Brain |
4 |
1 |
Detected, unquantifiable because contaminated |
||
| Tx2004 | 2.98 × 102 | Lungs | 7 | 0 | 0 |
| Spleen | 7 | 0 | 0 | ||
| Brain | 7 | 0 | 0 | ||
| 1.21 × 103 | Lungs | 6 | 1 | 5.29 × 107 | |
| Spleen | 6 | 1 | 1.20 × 109 | ||
| Brain | 6 | 1 | 1.25 × 102 |
Page created: June 09, 2026
Page updated: July 28, 2026
Page reviewed: July 28, 2026
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