Table 3

Outbreaks of Neuroinvasive Astrovirus Associated with Encephalomyelitis, Weakness, and Paralysis among Weaned Pigs, Hungary

Ákos Boros, Mihály Albert, Péter Pankovics, Hunor Bíró, Patricia A. Pesavento, Tung Gia Phan, Eric Delwart, and Gábor Reuter

Author affiliations: ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary (A. Boros, P. Pankovics, G. Reuter); University of Pécs, Pécs (A. Boros, P. Pankovics, G. Reuter); Ceva Phylaxia Ltd., Budapest, Hungary (M. Albert); SHP Ltd., Kaposvár, Hungary (H. Bíró); University of California, Davis, California, USA (P.A. Pesavento); Blood Systems Research Institute, San Francisco, California, USA (T.G. Phan, E. Delwart); University of California, San Francisco (E. Delwart)

Main Article

Amino acid differences between neuroinvasive PoAstV-3 strains from 3 symptomatic newly weaned pigs from a farm in Hungary and reference enteric PoAstV-3 strains detected from fecal samples*

Category	Genomic region
Category	ORF1a	ORF1a	ORF1a	ORF1a	ORF1b	ORF1b	ORF2	ORF2	ORF2	ORF2
Amino acid position	1–400	1–400	401–844	401–844	1–508	1–508	1–415 (AD)	1–415 (AD)	416–754 (RID)	416–754 (RID)
PoAstV-3 type	Ni	Ent	Ni	Ent	Ni	Ent	Ni	Ent	Ni	Ent
Amino acid changes	M25	S/L	F408	L	N54	D	R29N	KT[I/A/V]	L439	H[P/V]
	Y41	F	I434	V	D106G	[A/E]D	S34	R	S453	D
	R117	K	S481	P	A181	S	R38	Y	F457	Y
	T120	S/L	S576	T/V	I206	V	V55	T	Y559	F
	T122	S/L	G608	N	R213	K	T57R	SK	A570[P]	N
	K151G	RC	N646	H	Y293	H/N	T61	A	N572[Y]	D
	L170	M	E679	D	E343	D			D581	N
	L179	M			K375	R			I601	V
	M185	L			I378	T			S617	N
	D208	E/N			N382	D			T628	S
	D202S[P/Q]–	NPTDG			I415	A/T			S678	T
	P217A	TT							I696	V
	T220[V/A]	IS
	P224	H/R
	I299	V
	E332	D
	V338	L/I
	L346	F
	I369	V

*We identified 3 PoAstV-3 isolates: NI-Brain/9-2016a/HUN (GenBank accession no. KY073230); NI-Brain/173-2016a/HUN (accession no. KY073231); and NI-Brain/386-2015/HUN (accession no. KY073232). We compared these with enteric strains from GenBank (accession nos. JX556691, LC201595-7, and LC201599). AD, presumed particle assembly domain; Ent, enteric; Ni, neuroinvasive; ORF, open reading frame; PoAstV-3, porcine astrovirus type 3; RID, presumed receptor-interaction domain.

Main Article

Page created: November 16, 2017

Page updated: November 16, 2017

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