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Volume 31, Number 8—August 2025

Research

Rapid Emergence and Evolution of SARS-CoV-2 Intrahost Variants among COVID-19 Patients with Prolonged Infections, Singapore

Yvonne C.F. SuComments to Author , Michael A. Zeller, Peter Cronin, Rong Zhang, Yan Zhuang, Jordan Ma, Foong Ying Wong, Giselle G.K. Ng, Áine O’Toole, Andrew Rambaut, Jenny G. Low, and Gavin J.D. Smith
Author affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore (Y.C.F. Su, M.A. Zeller, P. Cronin, R. Zhang, Y. Zhang, J. Ma, F.Y. Wong, G.G.K. Ng, J.G. Low, G.J.D. Smith); Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland, UK (A. O’Toole, A. Rambaut); Singapore General Hospital, Singapore (J.G. Low)

Main Article

Figure 5

Comparative analysis of variants among lineages and infection durations in study of rapid emergence and evolution of SARS-CoV-2 iSNVs among COVID-19 patients with prolonged infections, Singapore. A, B) Variant frequency between B.1 lineages (A) and B.6 or B.6.6 lineages (B). Red arrows indicate the appearance of intrahost D614G spike variant at nucleotide position 23403. C, D) Variant frequency between COVID-19 patients with shorter infections (<7 days) (C) and those with prolonged infections (8–40 days) (D). Colored circles represent the number of patients with co-occurring intrahost variants; circle size is proportional to patient count. iSNVs, intrahost single-nucleotide variants.

Figure 5. Comparative analysis of variants among lineages and infection durations in study of rapid emergence and evolution of SARS-CoV-2 iSNVs among COVID-19 patients with prolonged infections, Singapore. A, B) Variant frequency between B.1 lineages (A) and B.6 or B.6.6 lineages (B). Red arrows indicate the appearance of intrahost D614G spike variant at nucleotide position 23403. C, D) Variant frequency between COVID-19 patients with shorter infections (<7 days) (C) and those with prolonged infections (8–40 days) (D). Colored circles represent the number of patients with co-occurring intrahost variants; circle size is proportional to patient count. iSNVs, intrahost single-nucleotide variants.

Main Article

Page created: May 31, 2025
Page updated: July 21, 2025
Page reviewed: July 21, 2025
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