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Volume 31, Number 8—August 2025

Research

Rapid Emergence and Evolution of SARS-CoV-2 Intrahost Variants among COVID-19 Patients with Prolonged Infections, Singapore

Yvonne C.F. SuComments to Author , Michael A. Zeller, Peter Cronin, Rong Zhang, Yan Zhuang, Jordan Ma, Foong Ying Wong, Giselle G.K. Ng, Áine O’Toole, Andrew Rambaut, Jenny G. Low, and Gavin J.D. Smith
Author affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore (Y.C.F. Su, M.A. Zeller, P. Cronin, R. Zhang, Y. Zhang, J. Ma, F.Y. Wong, G.G.K. Ng, J.G. Low, G.J.D. Smith); Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland, UK (A. O’Toole, A. Rambaut); Singapore General Hospital, Singapore (J.G. Low)

Main Article

Table 2

Clinical features of patients in a study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore*

Characteristics All patients, n = 20
Median age, y (range)
 38 (21–70)
Sex
F 6 (30)
M
 14 (70)
Healthcare worker
 2 (10)
Median height, cm (range) 168 (151–185)
Median weight, kg (range) 69.2 (42.5–95.1)
Median BMI (range)
 25.8 (14.7–31.8)
Hypertension
 4 (20)
Intensive care unit admission 2 (10)
Median length of hospitalization, d (range)
 7 (4–40)
Median CRP, mg/L (IQR)
 41.53 (14.1–109.7)
Median leukocyte count, cells × 109/L (range) 4.99 (2.5–21.7)
Median lymphocyte count, cells × 109/L (IQR)
 1.27 (0.97–1.68)
Remdesivir treatment 5 (25)
Long-term medication
 4 (20)
International travel 8 (40)

*Values are no. (%) except as indicated. BMI, body mass index; CRP, C-reactive protein; IQR, interquartile range.

Main Article

Page created: May 31, 2025
Page updated: July 01, 2025
Page reviewed: July 01, 2025
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