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Volume 31, Number 8—August 2025

Research

Rapid Emergence and Evolution of SARS-CoV-2 Intrahost Variants among COVID-19 Patients with Prolonged Infections, Singapore

Yvonne C.F. SuComments to Author , Michael A. Zeller, Peter Cronin, Rong Zhang, Yan Zhuang, Jordan Ma, Foong Ying Wong, Giselle G.K. Ng, Áine O’Toole, Andrew Rambaut, Jenny G. Low, and Gavin J.D. Smith
Author affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore (Y.C.F. Su, M.A. Zeller, P. Cronin, R. Zhang, Y. Zhang, J. Ma, F.Y. Wong, G.G.K. Ng, J.G. Low, G.J.D. Smith); Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland, UK (A. O’Toole, A. Rambaut); Singapore General Hospital, Singapore (J.G. Low)

Main Article

Figure 7

Correlation between iSNVs and clinical parameters in study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore. Correlation matrix illustrates the relationships between the number of iSNVs and various clinical variables. Asterisk denotes duration of infection. Colored gradient indicates the degree of pairwise correlation with respect to Pearson correlation coefficient. Blue ellipsoids represent positive associations between any pairwise variables; orange ellipsoids denote negative correlations; the darker and narrower blue ellipsoids indicate stronger positive correlations. Black X denotes correlations that are not statistically significant (p>0.05). BMI, body mass index; CRP, C-reactive protein; ICU, intensive care unit; iSNVs, intrahost-single nucleotide variants.

Figure 7. Correlation between iSNVs and clinical parameters in study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore. Correlation matrix illustrates the relationships between the number of iSNVs and various clinical variables. Asterisk denotes duration of infection. Colored gradient indicates the degree of pairwise correlation with respect to Pearson correlation coefficient. Blue ellipsoids represent positive associations between any pairwise variables; orange ellipsoids denote negative correlations; the darker and narrower blue ellipsoids indicate stronger positive correlations. Black X denotes correlations that are not statistically significant (p>0.05). BMI, body mass index; CRP, C-reactive protein; ICU, intensive care unit; iSNVs, intrahost-single nucleotide variants.

Main Article

Page created: May 31, 2025
Page updated: July 01, 2025
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