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Volume 31, Number 8—August 2025

Research

Rapid Emergence and Evolution of SARS-CoV-2 Intrahost Variants among COVID-19 Patients with Prolonged Infections, Singapore

Yvonne C.F. SuComments to Author , Michael A. Zeller, Peter Cronin, Rong Zhang, Yan Zhuang, Jordan Ma, Foong Ying Wong, Giselle G.K. Ng, Áine O’Toole, Andrew Rambaut, Jenny G. Low, and Gavin J.D. Smith
Author affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore (Y.C.F. Su, M.A. Zeller, P. Cronin, R. Zhang, Y. Zhang, J. Ma, F.Y. Wong, G.G.K. Ng, J.G. Low, G.J.D. Smith); Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland, UK (A. O’Toole, A. Rambaut); Singapore General Hospital, Singapore (J.G. Low)

Main Article

Figure 4

Evolutionary landscape in study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore. A) Number of SARS-CoV-2 cases carrying the spike 614D or 614G mutations in all available SARS-CoV-2–positive samples. Dotted red line shows the first detection of the 614G mutation in Singapore. B, C) Percentages of different SARS-CoV-2 Pango lineages containing the 614D (B) or 614G (C) residues in the spike protein.

Figure 4. Evolutionary landscape in study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore. A) Number of SARS-CoV-2 cases carrying the spike 614D or 614G mutations in all available SARS-CoV-2–positive samples. Dotted red line shows the first detection of the 614G mutation in Singapore. B, C) Percentages of different SARS-CoV-2 Pango lineages containing the 614D (B) or 614G (C) residues in the spike protein.

Main Article

Page created: May 31, 2025
Page updated: July 21, 2025
Page reviewed: July 21, 2025
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