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Volume 31, Number 8—August 2025

Research

Rapid Emergence and Evolution of SARS-CoV-2 Intrahost Variants among COVID-19 Patients with Prolonged Infections, Singapore

Yvonne C.F. SuComments to Author , Michael A. Zeller, Peter Cronin, Rong Zhang, Yan Zhuang, Jordan Ma, Foong Ying Wong, Giselle G.K. Ng, Áine O’Toole, Andrew Rambaut, Jenny G. Low, and Gavin J.D. Smith
Author affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore (Y.C.F. Su, M.A. Zeller, P. Cronin, R. Zhang, Y. Zhang, J. Ma, F.Y. Wong, G.G.K. Ng, J.G. Low, G.J.D. Smith); Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland, UK (A. O’Toole, A. Rambaut); Singapore General Hospital, Singapore (J.G. Low)

Main Article

Figure 3

Temporal dynamics of 76 high-frequency iSNVs in study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore. Colored closed circles represent synonymous variants; colored open circles represent nonsynonymous variants; crossed dots indicate variants at UTRs. Nucleotide positions of each iSNV are shown above the gray panels. The gradient of colored circles corresponds to iSNVs at respective nucleotide positions. Intrahost variants associated with persistent infections are highlighted in blue bold font, including the D614G intrahost variant (nucleotide position 23403), which marked is in red font above the corresponding open circles. Red rectangles indicate selected variants and their corresponding amino acid substitutions. iSNV, intrahost single-nucleotide variant; N, nucleocapsid; nsp, nonstructural protein; UTR, untranslated region.

Figure 3. Temporal dynamics of 76 high-frequency iSNVs in study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore. Colored closed circles represent synonymous variants; colored open circles represent nonsynonymous variants; crossed dots indicate variants at UTRs. Nucleotide positions of each iSNV are shown above the gray panels. The gradient of colored circles corresponds to iSNVs at respective nucleotide positions. Intrahost variants associated with persistent infections are highlighted in blue bold font, including the D614G intrahost variant (nucleotide position 23403), which marked is in red font above the corresponding open circles. Red rectangles indicate selected variants and their corresponding amino acid substitutions. iSNV, intrahost single-nucleotide variant; N, nucleocapsid; nsp, nonstructural protein; UTR, untranslated region.

Main Article

Page created: May 31, 2025
Page updated: July 01, 2025
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