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Volume 31, Number 8—August 2025

Research

Rapid Emergence and Evolution of SARS-CoV-2 Intrahost Variants among COVID-19 Patients with Prolonged Infections, Singapore

Yvonne C.F. SuComments to Author , Michael A. Zeller, Peter Cronin, Rong Zhang, Yan Zhuang, Jordan Ma, Foong Ying Wong, Giselle G.K. Ng, Áine O’Toole, Andrew Rambaut, Jenny G. Low, and Gavin J.D. Smith
Author affiliation: Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore (Y.C.F. Su, M.A. Zeller, P. Cronin, R. Zhang, Y. Zhang, J. Ma, F.Y. Wong, G.G.K. Ng, J.G. Low, G.J.D. Smith); Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, Scotland, UK (A. O’Toole, A. Rambaut); Singapore General Hospital, Singapore (J.G. Low)

Main Article

Table 3

Pearson correlation matrix of iSNV counts and clinical characteristics patients in a study of rapid emergence and evolution of SARS-CoV-2 intrahost variants among COVID-19 patients with prolonged infections, Singapore*

Characteristic Age Sex Height Weight BMI Underlying conditions† ICU admission Infection duration Leukocyte count Remdesivir treatment CRP iSNV counts
Age – 0.00 –0.56 0.16 0.54 0.71 0.54 0.79 0.54 0.72 0.77 0.58
Sex
–
 0.43
 0.35
 0.04
 0.32
 0.22
 0.22
 0.26
 –0.05
 –0.02
 0.21
Height – 0.30 −0.39 –0.09 –0.16 –0.38 –0.36 –0.50 –0.43 –0.21
Weight – 0.75 0.04 –0.38 –0.18 –0.40 –0.18 –0.32 –0.26
BMI
–
 0.08
 –0.26
 0.08
 −0.13
 0.22
 0.02
 −0.10
Underlying conditions† – 0.81 0.88 0.73 0.32 0.70 0.55
ICU admission – 0.92 0.85 0.51 0.88 0.80
Infection duration
–
 0.90
 0.66
 0.91
 0.78
Leukocyte count – 0.55 0.76 0.66
Remdesivir treatment – 0.76 0.81
CRP – 0.78
iSNV counts –

*Bold text indicates p<0.05. BMI, body mass index; CRP, C-reactive protein; ICU, intensive care unit; iSNV, intrahost single nucleotide variant. †Including hypertension or hyperlipidemia.

Main Article

Page created: May 31, 2025
Page updated: July 01, 2025
Page reviewed: July 01, 2025
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