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Volume 31, Number 12—December 2025

Research

Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep

Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier AndreolettiComments to Author 
Author affiliation: University of Toulouse, ENVI, INRAE, IHAP, Toulouse, France (A. Huor, J.-Y. Douet, S. Lugan, N. Aron, C. Mesic, H. Cassard, T. Barrio, O. Andreoletti); National Research Institute for Agriculture, Food and Environment, Nouzilly, France (F. Lantier, I. Lantier); Animal and Plant Health Agency, Weybridge, UK (H. Simmons)

Main Article

Figure 2

Protein misfolding cyclic amplification (PMCA) seeding activity levels in ARR/ARR and ARQ/ARQ sheep tissues after classical bovine spongiform encephalopathy challenge in study of oral transmission of classical bovine spongiform encephalopathy in ARR/ARR sheep. A) ARQ/ARQ sheep. B) ARR/ARR sheep. Protein misfolding cyclic amplification products were analyzed by using Western blot for proteinase K–resistant core prion protein detection. Each symbol represents a different animal and the associated tissue tested. Cerv, cervical; duo, duodenum; jeju, jejunum; LN, lymph node; lumb, lumbar; med, medial; mesen, mesenteric; Neg, negative; pp, Peyer’s patches; prescap, prescapular; thor, thorasic.

Figure 2. Protein misfolding cyclic amplification (PMCA) seeding activity levels in ARR/ARR and ARQ/ARQ sheep tissues after classical bovine spongiform encephalopathy challenge in study of oral transmission of classical bovine spongiform encephalopathy in ARR/ARR sheep. A) ARQ/ARQ sheep. B) ARR/ARR sheep. Protein misfolding cyclic amplification products were analyzed by using Western blot for proteinase K–resistant core prion protein detection. Each symbol represents a different animal and the associated tissue tested. Cerv, cervical; duo, duodenum; jeju, jejunum; LN, lymph node; lumb, lumbar; med, medial; mesen, mesenteric; Neg, negative; pp, Peyer’s patches; prescap, prescapular; thor, thorasic.

Main Article

1These first authors contributed equally to this article.

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