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Volume 31, Number 12—December 2025

Research

Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep

Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier AndreolettiComments to Author 
Author affiliation: University of Toulouse, ENVI, INRAE, IHAP, Toulouse, France (A. Huor, J.-Y. Douet, S. Lugan, N. Aron, C. Mesic, H. Cassard, T. Barrio, O. Andreoletti); National Research Institute for Agriculture, Food and Environment, Nouzilly, France (F. Lantier, I. Lantier); Animal and Plant Health Agency, Weybridge, UK (H. Simmons)

Main Article

Figure 3

Detection of proteinase K–resistant core prion protein after 2 PMCA rounds of ARR/ARR and ARQ/ARQ sheep tissues after classical BSE challenge in study of oral transmission of BSE in ARR/ARR sheep. A) ARQ/ARQ sheep samples. B) ARR/ARR sheep samples. Western blot results from protein misfolding cyclic amplification products showing a detectable proteinase K–resistant core prion protein in >2 of 4 replicates for each tissue and animal. BSE, bovine spongiform encephalopathy; LN, lymph node; mesen, mesenteric; mpi, months postinoculation; prescap, prescapular.

Figure 3. Detection of proteinase K–resistant core prion protein after 2 PMCA rounds of ARR/ARR and ARQ/ARQ sheep tissues after classical BSE challenge in study of oral transmission of BSE in ARR/ARR sheep. A) ARQ/ARQ sheep samples. B) ARR/ARR sheep samples. Western blot results from protein misfolding cyclic amplification products showing a detectable proteinase K–resistant core prion protein in >2 of 4 replicates for each tissue and animal. BSE, bovine spongiform encephalopathy; LN, lymph node; mesen, mesenteric; mpi, months postinoculation; prescap, prescapular.

Main Article

1These first authors contributed equally to this article.

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