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Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 12—December 2025

Research

Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep

Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier AndreolettiComments to Author 
Author affiliation: University of Toulouse, Toulouse, France (A. Huor, J.-Y. Douet, S. Lugan, N. Aron, C. Mesic, H. Cassard, T. Barrio, O. Andreoletti); National Research Institute for Agriculture, Food and Environment, Nouzilly, France (F. Lantier, I. Lantier); Animal and Plant Health Agency, Weybridge, UK (H. Simmons)

Main Article

Figure 3

Detection of proteinase K–resistant core prion protein after 2 PMCA rounds of ARR/ARR and ARQ/ARQ sheep tissues after classical BSE challenge in study of oral transmission of BSE in ARR/ARR sheep. A) ARQ/ARQ sheep samples. B) ARR/ARR sheep samples. Western blot results from protein misfolding cyclic amplification products showing a detectable proteinase K–resistant core prion protein in >2 of 4 replicates for each tissue and animal. BSE, bovine spongiform encephalopathy; LN, lymph node; mesen, mesenteric; mpi, months postinoculation; prescap, prescapular.

Figure 3. Detection of proteinase K–resistant core prion protein after 2 PMCA rounds of ARR/ARR and ARQ/ARQ sheep tissues after classical BSE challenge in study of oral transmission of BSE in ARR/ARR sheep. A) ARQ/ARQ sheep samples. B) ARR/ARR sheep samples. Western blot results from protein misfolding cyclic amplification products showing a detectable proteinase K–resistant core prion protein in >2 of 4 replicates for each tissue and animal. BSE, bovine spongiform encephalopathy; LN, lymph node; mesen, mesenteric; mpi, months postinoculation; prescap, prescapular.

Main Article

1These first authors contributed equally to this article.

Page created: November 18, 2025
Page updated: December 23, 2025
Page reviewed: December 23, 2025
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