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Volume 31, Number 12—December 2025
Research
Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep
Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier Andreoletti
Table 1
Results of intracerebral inoculation of transgenic mice expressing bovine prion protein with a panel of bovine and ovine prion isolates in a study of oral transmission of classical bovine spongiform encephalopathy in ARR/ARR sheep*
| Inoculum | Passage 1 |
Passage 2 |
|||
|---|---|---|---|---|---|
| No. positive/no. tested | Survival, dpi ±SD | No. positive/no. tested | Survival, dpi ±SD | ||
| Cattle BSE | 6/6 | 295 ±12 | 6/6 | 265 ±35 | |
| ARQ Ov-BSE | 6/6 | 229 ±11 | 6/6 | 237 ±5 | |
| ARR Ov-BSE | 6/6 | 375 ±78 | 6/6 | 238 ±9 | |
| Negative brain | 0/6 | >750 | 0/6 | >750 | |
| Phosphate buffered saline control | 0/6 | >750 | 0/6 | >750 | |
*BSE, bovine spongiform encephalopathy; dpi, days postinoculation; ov, ovine.
1These first authors contributed equally to this article.
Page created: November 18, 2025
Page updated: December 23, 2025
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