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Volume 31, Number 12—December 2025

Research

Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep

Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier AndreolettiComments to Author 
Author affiliation: University of Toulouse, ENVI, INRAE, IHAP, Toulouse, France (A. Huor, J.-Y. Douet, S. Lugan, N. Aron, C. Mesic, H. Cassard, T. Barrio, O. Andreoletti); National Research Institute for Agriculture, Food and Environment, Nouzilly, France (F. Lantier, I. Lantier); Animal and Plant Health Agency, Weybridge, UK (H. Simmons)

Main Article

Table 2

Intracerebral inoculation of tgMet humanized mice with a panel of human, bovine, and ovine prion isolates in a study of oral transmission of classical bovine spongiform encephalopathy in ARR/ARR sheep*

Isolate Passage 1
 Passage 2
No. positive/no. tested Survival, dpi ±SD No. positive/no. tested Survival, dpi ±SD
Cattle BSE 1/6† >750 3/6 572 ±64
ARQ Ov-BSE 4/6 560 ±83 6/6 569 ±55
ARR Ov-BSE 1/7 737 5/6 616 ±83
Negative brain 0/12 >750 0/12 >750
Phosphate buffered saline control 0/18 >800 0/12 >650

*BSE, bovine spongiform encephalopathy; dpi, days postinoculation; ov, ovine. †Abnormal prion protein isoform positive brain in a found dead animal without clinical manifestations of transmissible spongiform encephalopathies.

Main Article

1These first authors contributed equally to this article.

Page created: November 18, 2025
Page updated: January 01, 2026
Page reviewed: January 01, 2026
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