Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.
Volume 31, Number 12—December 2025
Research
Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep
Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier Andreoletti
Table 3
Intracerebral inoculation of tgVal humanized mice with a panel of human, bovine, and ovine prion isolates in a study of oral transmission of classical bovine spongiform encephalopathy in ARR/ARR sheep*
| Isolate | Passage 1 |
Passage 2 |
|||
|---|---|---|---|---|---|
| No. positive/no. tested | Survival, dpi ±SD | No. positive/no. tested | Survival, dpi ±SD | ||
| Cattle BSE | 0/6 | >750 | 0/6 | >750 | |
| ARQ Ov-BSE | 0/6 | >750 | 0/6 | >750 | |
| ARR Ov-BSE | 0/6 | >750 | 0/6 | >750 | |
| Negative brain | 0/12 | >750 | 0/6 | >750 | |
| Phosphate buffered saline control | 0/12 | >750 | 0/6 | >750 | |
*BSE, bovine spongiform encephalopathy; dpi, days postinoculation; ov, ovine.
1These first authors contributed equally to this article.
Page created: November 18, 2025
Page updated: December 23, 2025
Page reviewed: December 23, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.