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Volume 31, Number 12—December 2025

Research

Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep

Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier AndreolettiComments to Author 
Author affiliation: University of Toulouse, ENVI, INRAE, IHAP, Toulouse, France (A. Huor, J.-Y. Douet, S. Lugan, N. Aron, C. Mesic, H. Cassard, T. Barrio, O. Andreoletti); National Research Institute for Agriculture, Food and Environment, Nouzilly, France (F. Lantier, I. Lantier); Animal and Plant Health Agency, Weybridge, UK (H. Simmons)

Main Article

Table 4

Intracerebral inoculation of tgMet/tgVal humanized mice with a panel of human, bovine, and ovine prion isolates in a study of oral transmission of classical bovine spongiform encephalopathy in ARR/ARR sheep*

Isolate Passage 1
 Passage 2
No. positive/no. tested Survival, dpi ±SD No. positive/no. tested Survival, dpi ±SD
Cattle BSE 0/6 >750 NA NA
ARQ Ov-BSE 0/6 >750 NA NA
ARR Ov-BSE 0/6 >750 0/6 >750
Negative brain 0/12 >750 0/6 >650
Phosphate buffered saline control 0/12 >750 0/6 >650

*BSE, bovine spongiform encephalopathy; dpi, days postinoculation; NA, not available; ov, ovine.

Main Article

1These first authors contributed equally to this article.

Page created: November 18, 2025
Page updated: January 01, 2026
Page reviewed: January 01, 2026
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