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Volume 31, Number 12—December 2025

Research

Oral Transmission of Classical Bovine Spongiform Encephalopathy in ARR/ARR Sheep

Alvina Huor1, Frederic Lantier1, Jean-Yves Douet, Severine Lugan, Naima Aron, Chloe Mesic, Herve Cassard, Tomás Barrio, Hugh Simmons, Isabelle Lantier, and Olivier AndreolettiComments to Author 
Author affiliation: University of Toulouse, ENVI, INRAE, IHAP, Toulouse, France (A. Huor, J.-Y. Douet, S. Lugan, N. Aron, C. Mesic, H. Cassard, T. Barrio, O. Andreoletti); National Research Institute for Agriculture, Food and Environment, Nouzilly, France (F. Lantier, I. Lantier); Animal and Plant Health Agency, Weybridge, UK (H. Simmons)

Main Article

Figure 5

Transmission of ARR/ARR and ARQ/ARQ ovine c-BSE to tgBov mice in study of oral transmission of c-BSE in ARR/ARR sheep. A) Vacuolar lesion profiles in tgBov mice inoculated with ARQ/ARQ and ARR/ARR c-BSE isolates. B) Profiles from tgBov mice inoculated with cattle-derived c-BSE were used as controls. Lesion scoring evaluated 9 grey matter regions and 3 white matter regions. White triangles represent mice inoculated with ARQ/ARQ c-BSE isolates. Black triangles represent mice inoculated with ARR/ARR c-BSE isolates. Black circles represent mice inoculated with cattle-derived c-BSE isolates. c-BSE, classical bovine spongiform encephalopathy; G, grey matter region; tgBov, bovine prion protein–expressing mice; W, white matter region.

Figure 5. Transmission of ARR/ARR and ARQ/ARQ ovine c-BSE to tgBov mice in study of oral transmission of c-BSE in ARR/ARR sheep. A) Vacuolar lesion profiles in tgBov mice inoculated with ARQ/ARQ and ARR/ARR c-BSE isolates. B) Profiles from tgBov mice inoculated with cattle-derived c-BSE were used as controls. Lesion scoring evaluated 9 grey matter regions and 3 white matter regions. White triangles represent mice inoculated with ARQ/ARQ c-BSE isolates. Black triangles represent mice inoculated with ARR/ARR c-BSE isolates. Black circles represent mice inoculated with cattle-derived c-BSE isolates. c-BSE, classical bovine spongiform encephalopathy; G, grey matter region; tgBov, bovine prion protein–expressing mice; W, white matter region.

Main Article

1These first authors contributed equally to this article.

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