Author(s): Lucy McNamara, Amy Blain

Infectious Agent

Neisseria meningitidis is a gram-negative diplococcus bacterium. Meningococci are classified into serogroups based on the composition of their capsular polysaccharide. The 6 major meningococcal serogroups associated with disease are A, B, C, W, X, and Y.

Transmission

Meningococci spread through respiratory secretions and require close contact for transmission. Both asymptomatic carriers and people with overt meningococcal disease can be sources of infection. Asymptomatic carriage is transient and typically affects ≈5%–10% of the population at any given time.

Epidemiology

N. meningitidis is found worldwide, but incidence is greatest in the “meningitis belt” of sub-Saharan Africa (Map 5-01). Meningococcal disease is hyperendemic in this region, and periodic epidemics during the dry season (December–June) reach an incidence of up to 1,000 cases per 100,000 population. By contrast, rates of disease in Australia, Europe, South America, and the United States range from 0.10–2.4 cases per 100,000 population per year.

Although meningococcal disease outbreaks can occur anywhere in the world, they are most common in the African meningitis belt, where large-scale epidemics occur every 5–12 years. Historically, outbreaks in the meningitis belt were primarily due to serogroup A. With the introduction of a monovalent serogroup A meningococcal conjugate vaccine (MenAfriVac) in the region starting in 2010, however, recent meningococcal outbreaks in the meningitis belt have primarily been caused by serogroups C and W; serogroup X outbreaks also have been reported.

Outside the meningitis belt, infants, adolescents, and adults >80 years of age have the highest rates of disease. In meningitis belt countries, high rates of disease are seen in people ≤30 years old; the highest rates are in children and adolescents aged 5–14 years.

Unvaccinated travelers visiting meningitis belt countries and having prolonged contact with local populations during an epidemic are at greatest risk for meningococcal disease. The Hajj pilgrimage to Saudi Arabia also has been associated with outbreaks of meningococcal disease among returning pilgrims and their contacts, including 4 cases in travelers from the United States during a large Hajj-associated outbreak in 2000.

Clinical Presentation

Meningococcal disease generally occurs 1–10 days after exposure and presents as meningitis in ≈50% of cases in the United States. Meningococcal meningitis is characterized by sudden onset of headache, fever, and neck stiffness, sometimes accompanied by nausea, vomiting, photophobia, or altered mental status. Meningococcal disease progresses rapidly and has a case-fatality rate of 10%–15%, even with antimicrobial drug treatment. Without rapid treatment, fatality rates can be much higher.

Approximately 30% of people with meningococcal disease present with meningococcal sepsis, known as meningococcemia. Symptoms of meningococcemia can include abrupt onset of fever, chills, vomiting, diarrhea, and a petechial or purpuric rash, which can progress to purpura fulminans. Meningococcemia often involves hypotension, acute adrenal hemorrhage, and multiorgan failure. An additional 15% of meningococcal disease cases in the United States, primarily among adults >65 years of age, present as bacteremic pneumonia.

Other presentations (e.g., septic arthritis) also occur. Among infants and children aged <2 years, meningococcal disease can have nonspecific symptoms. Neck stiffness, usually seen in people with meningitis, might be absent in this age group.

Diagnosis

Early diagnosis and treatment are critical. If bacterial meningitis is suspected, collect blood for culture right away and perform a lumbar puncture (LP) to collect cerebrospinal fluid (CSF) for microscopic examination and Gram stain. In general, diagnosis is made by isolating N. meningitidis from a normally sterile body site (e.g., blood, CSF) either by culture or by PCR detection of N. meningitidis–specific nucleic acid. State health departments can provide diagnostic and testing support if needed.

Signs and symptoms of meningococcal meningitis are like those of other causes of bacterial meningitis (e.g., Haemophilus influenzae, Streptococcus pneumoniae). Proper treatment and prophylaxis depend on correctly identifying the causative organism. Meningococcal disease is nationally notifiable in the United States; report cases to the state or local health department without delay.

Treatment

Meningococcal disease can be rapidly fatal and should always be viewed as a medical emergency. As soon as disease is suspected and blood cultures and CSF have been collected, deliver appropriate treatment; if the LP is to be delayed for any reason (e.g., imaging studies of the head prior to LP), administer antimicrobial drugs immediately after collecting blood cultures. Begin empiric antimicrobial drug treatment early and prior to receiving diagnostic test results.

Third-generation cephalosporins are recommended for empiric treatment. Although ampicillin or penicillin also can be used for treatment, determine meningococcal isolate susceptibility before switching to one of these antibiotics; recent reports indicate emerging penicillin resistance among meningococcal isolates in the United States. If a patient presents with suspected bacterial meningitis of uncertain etiology, some treatment algorithms recommend empiric use of dexamethasone in addition to an antimicrobial drug until a bacterial etiology is established; if meningococcal meningitis is confirmed or suspected, steroids can be discontinued.

Prevention

Vaccine

Five meningococcal vaccines (3 quadrivalent, 2 monovalent) are licensed and available in the United States. Travelers should receive vaccines 7–10 days before travel to enable time for protective antibody levels to develop. See Table 5-03 for more information about available meningococcal vaccines.

Routine Immunization

The Advisory Committee on Immunization Practices (ACIP) recommends routine administration of a quadrivalent meningococcal conjugate vaccine (MenACWY) for all people aged 11–18 years. Administer a single dose of vaccine to patients at age 11 or 12 years and a booster dose at age 16 years. Routine immunization with MenACWY is not recommended for other age groups in the United States, except for people at increased risk for meningococcal disease, including those with a persistent complement component deficiency (C3, C5-9, properdin, factor D, factor H); people taking a complement component inhibitor (e.g., eculizumab [Soliris] or ravulizumab [Ultomiris]); people who have functional or anatomic asplenia; or people with HIV. ACIP describes vaccine, product, number of doses, and booster dose recommendations, based on age and risk factors for each risk group, in Meningococcal Vaccination: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.

ACIP also recommends adolescents and young adults aged 16–23 years be vaccinated with a serogroup B meningococcal (MenB) vaccine series, based on shared clinical decision-making. A MenB vaccine series provides short-term protection against most strains of serogroup B meningococcus; 16–18 years is the optimal age for MenB vaccination. ACIP also recommends routine use of MenB vaccine for people aged ≥10 years who are at increased risk for meningococcal disease, including people who have persistent complement component deficiency and those with functional or anatomic asplenia. ACIP recommendations for use of MenB vaccines can be found in Meningococcal Vaccination: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.

Immunization For Travelers

Quadrivalent Meningococcal Conjugate (MenACWY) Vaccines

ACIP recommends that travelers aged ≥2 months who visit or reside in parts of the meningitis belt of sub-Saharan Africa (see Map 5-01) during the dry season (December–June) receive vaccination with a MenACWY vaccine before travel. The Centers for Disease Control and Prevention (CDC) issues advisories for travelers to other countries when outbreaks of meningococcal disease are recognized; travelers should check the CDC Travelers’ Health website before travel. There are 3 meningococcal vaccines licensed and available in the United States for children; the age at vaccine initiation and schedule differs for each. See Table 5-03 for more information about meningococcal vaccines for young children.

The Kingdom of Saudi Arabia (KSA) requires travelers >2 years of age making the Umrah or Hajj pilgrimage to provide documentation of quadrivalent vaccine ≥10 days and ≤3 years before arrival for polysaccharide vaccine (MPSV4, no longer available in the United States) and ≤5 years before arrival for conjugate vaccine. Travelers should confirm visa requirements with the KSA embassy. Although the KSA Ministry of Health advises against travel to Hajj for pregnant people or children, these groups should receive meningococcal vaccination according to licensed indications for their age if they travel.

International travelers at risk for meningococcal disease who were previously vaccinated with a quadrivalent vaccine should receive a booster dose. For children who completed the primary dose or series at <7 years of age, administer a booster dose of MenACWY after 3 years and repeat every 5 years thereafter for those who live in or travel to hyperendemic areas. For people who received the primary dose or series at ≥7 years of age, administer a booster dose after 5 years and every 5 years thereafter for people who live in or travel to a hyperendemic area.

Monovalent Vaccines (Serogroups A, B & C)

In 2010, the Meningitis Vaccine Project introduced MenAfriVac, a monovalent serogroup A meningococcal conjugate vaccine, into meningitis belt countries through mass vaccination campaigns and the routine childhood immunization schedule. This vaccine is not licensed for use in the United States. US travelers going to live or work in the meningitis belt should receive a quadrivalent meningococcal conjugate vaccine (MenACWY) before leaving, to protect against 4 serogroups.

MenB vaccine is not recommended for people who live in or travel to meningitis belt countries, because serogroup B disease is extremely rare in this region. MenB vaccine is not routinely recommended for travelers to other regions of the world unless an outbreak of serogroup B disease has been reported.

In some countries outside the meningitis belt, meningococcal vaccination (e.g., monovalent conjugate C vaccine or MenB vaccine) might be recommended as part of the routine immunization program for infants. Clinicians can consider meningococcal vaccination for infants residing in these countries, according to the routine immunization recommendations of that country.

Safety & Adverse Reactions

Side effects after MenACWY vaccination include low-grade fevers and local reactions (e.g., injection-site pain, arm swelling, pain that limits movement of the injected arm). Symptoms are generally mild to moderate and resolve within 48–72 hours. Severe adverse events (e.g., high fever, chills, joint pain, rash, seizures) are rare (<5% of vaccinees).

Although no clinical trials of meningococcal vaccines have been conducted in people who are pregnant or lactating, post-licensure safety data have not identified any serious safety concerns to the mother or fetus. Pregnancy or lactation should not preclude vaccination with MenACWY if indicated.

Precautions & Contraindications

People with moderate or severe acute illness should defer vaccination until their condition improves. Vaccination is contraindicated for people who have had a severe allergic reaction to any component of the vaccines or to a prior dose of the vaccine. A severe allergic reaction to any diphtheria toxoid- or CRM197-containing vaccine also is a contraindication for MenACWY-D and MenACWY-CRM; severe allergic reaction to any tetanus toxoid–containing vaccine is a contraindication for MenACWY-TT.

To avoid interference with the immune response to meningococcal vaccine, MenACWY-D should be given either before or at the same time as DTaP in children. MenACWY-D may be given at any time in relation to Tdap or Td.

All meningococcal vaccines are inactivated and can be given to people who are immunosuppressed.

Postexposure Prophylaxis

In the United States and most industrialized countries, antibiotic chemoprophylaxis is recommended for close contacts of a patient with invasive meningococcal disease to prevent secondary cases. Chemoprophylaxis ideally should be initiated within 24 hours after the index patient is identified; prophylaxis given >2 weeks after exposure has little value.

Antibiotics used for prophylaxis include ceftriaxone, ciprofloxacin, and rifampin. Ceftriaxone is recommended for pregnant people. CDC provides detailed information on meningococcal prophylaxis in the Manual for the Surveillance of Vaccine-Preventable Diseases.

CDC website: Meningococcal disease